“PD-1 Blockade Promotes Epitope Spreading in Anti-cnacer CD8+ T cell Reponses by Preventing Fratricidal Death of Subdominant Clones To Relieve Immunodomination”  Arash Memarnejadian, S M Mansour Haeryfar, et al. (Nov 2017) J Immunol 199(9): 3348-59.  https://doi.org/10.4049/jimmunol.1700643.  PMID: 28939757   Often over time, an anti-Cancer immune response narrows into a few dominant (high affinity) CD8+ T […]

New Ancell TIGIT-muIg binds to CD155 on U-937 cells and to recombinant CD155-muIg in EIA!   The TIGIT – CD155 regulatory pathway is emerging as an important element of immune function.  Studies using knockout mice demonstrate that this pathway is important in optimal NK effector cell function (activation and/or tolerance) (1) There is significant potential

The CD47 – along with its ligand, SIRP alpha are now recognized as an important  regulatory element of innate immune function.  (1).  CD47 is described as a “don’t eat me” signal. However, it appears that CD47, along with Intraflagellar Transport Proteins 20 and 57 (IFT 20, IFT 57) are also involved in T cell receptor

CD268 (BAFF-R, TNFRSF13C) is a significant marker for B Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL). Ancell clone ANC268.2 was used to phenotype patient samples.  Blocking the BAFF – BAFFR pathway may prove to be useful in treating BCP-ALL.  “TNFRSF13C (BAFFR) positive blasts persist after early treatment and at relapse in childhood B-cell precursor acute lymphoblastic

The TIGIT – CD155 regulatory pathway is emerging as an important element of immune function.  Studies using knockout mice demonstrate that this pathway is important in optimal NK effector cell function (activation and/or tolerance) (1) There is significant potential for the development of immunological drugs that could blockade this pathway, restoring anti-cancer immune response (2).

Please visit Ancell at booth #812 May 13 -15 at the AAI meetings in Washington DC!

“Endothelial Cell Inflammatory Reactions Are Altered in the Presence of E-Cigarette Extracts of Variable Nicotine” Barber, K.E., Ghebrehiwet, B., Yin, W. et al. (2017) Cel. Mol. Bioeng. 10: 124. doi:10.1007/s12195-016-0465-4   The Authors utilized an in vitro model in which HUVEC (human umbilical cord endothelial cells) were exposed to tobacco vapor/ in HEPES buffer to

An Ohio research group tested the efficacy of inactivated Swine Influenza virus (SwlV) encapsulated in 200–300 nm diameter PLGA (poly lactic co-glycolic acid) microspheres. Pigs were immunized twice intranasaly.  While control pigs had fever for four days, treated pigs showed no clinical flu symptoms.  “Biodegradable nanoparticle delivery of inactivated swine influenza virus vaccine provides heterologous

CD36 is a scavenger receptor which can bind to various ligands as well as long chain fatty acids.  It plays a role in innate immunity as well as metabolism.  The authors use transport inhibitors, and uptake of 14-C labeled Phosphate diester of alpha-Tocopheryl (Vitamin E ) to implicate the CD36/PI3Ky as an important pathway for

Visit Ancell at the 2016 Autumn Immunology Conference Nov 18 – 20 at the downtown Marriott in Chicago!