CD36 is a scavenger receptor which can bind to various ligands as well as long chain fatty acids.  It plays a role in innate immunity as well as metabolism.  The authors use transport inhibitors, and uptake of 14-C labeled Phosphate diester of alpha-Tocopheryl (Vitamin E ) to implicate the CD36/PI3Ky as an important pathway for […]

Visit Ancell at the 2016 Autumn Immunology Conference Nov 18 – 20 at the downtown Marriott in Chicago!

Ancell anti-human FOXP3 mAb and Biotin conjugate now available!  Other conjugates coming soon!   Clone ANCFX2D7 Purified mAb   333-020 Biotinylated    333-030 FITC              333-040 PE                333-050

“Single CD28 stimulation induces stable and polyclonal expansion of human regulatory T cells” Xuehui He, Ruben L Smeets,  Esther van Rijssen, Annemieke MH Boots, Irma Joosten, Hans JPM Koenen.  (2016) Dissertation Submitted for Publication,  Radbound Univ Med Center and Groningen Univ Med Center, The Netherlands. Ancell anti-CD28 Superagonist  Clone ANC28.1/5D10

Adding Low density lipoprotein to FITC labeled Group A Steptococcus increased U-937 phagocytosis rate.   This effect was blocked when cells were pre incubated with Ancell anti-CD36 mAb clone SMO. “LDL acts as an opsonin enhancing the phagocytosis of group A Streptococcus by monocyte and whole human blood”  Lulei Zhou, Runlin Han, et al. (2016) Medical

Come and visit Ancell at the American Association of Immunologist’s meeting in Seattle May 13 – May 16th, booth #816.  Ask for an Ancell  T shirt.  They go fast!

Macrophages derived in culture from SLE patients are directed into secreting proinflammatory cytokines by anti-C1q auto antibodies bound to immobilized C1q complement protein. Pre blocking these monocytes with anti-CD32 (FcgRII ) F(ab’)2 reduced cytokine secretion levels significantly. “Anti-C1q Autoantibodies from Systemic Lupus Erythematosus Patients Induce a Proinflammatory Phenotype in Macrophages.”  Sophia Thanei, Marten Trendelenburg  J

Using TALEN(Transcription Activator-Like Effector Nucleases) technology, these researchers from Seattle Children’s Research succeeded in restoring copies of CD154( CD40L) gene with 3’ UTR under control of its endogenous promoter in human T cells from a patient with X-Linked Hyper-IgM Syndrome (X-HIGM). “Targeted gene editing restores regulated CD40L expression and function in X-HIGM T cells.” N

Neutrophil Extracellular Trap (NET) is a mechanism by which bacteria and other pathogenic organisms are rendered trapped in a site of inflammation.  An activated Neutrophil extrudes it own genomic DNA, rich with histones and other proteins, to trap invading pathogenic organisms.  However, in SLE patients, a distinct subset of Neutrophils, Low Density Granulocytes (LDGs) are

“Assessment of costimulation and coinhibition in a triple parameter T cell reporter line: Simultaneous measurement of NF-κB, NFAT and AP-1” S Jutz, P Steinberger, et al. (2016)  J Immunol Methods pii: S0022-1759(16)30007-2.  PMID: 26780292   Relevant Ancell Products   anti-human TCR Cb1 mAb   anti-human CD3e mAb CD272(BTLA) CD279(PD-1) CD137(4-1BB) anti-human CD28 (superagonist) mAb