Blockade of CD274(PD-L1, B7-H1) restores T cell function to clear Herpes Simplex 1 virus from infected mouse cornea in vivo

Interfering with the CD279(PD-1) – CD274(PD-L1) axis has shown great promise in restoring anti-cancer T cell function.  This Pittsburgh research group has used a similar approach in a mouse HSV-1 model to improve T cell mediated viral clearance from the immunologically sequestered cornea.


“PD-L1/B7-H1 Inhibits Viral Clearance by Macrophages in HSV-1–Infected Corneas” Sohyun Jeon, Alexander M. Rowe, Kate L. Carroll, Stephen A. K. Harvey and Robert L. Hendricks J Immunol June 1, 2018, 200 (11) 3711-3719; DOI:


Related Ancell Products 

anti-human CD274(PD-L1) mAb

anti-human CD279(PD-1) mAb

anti-human CD273(PD-L2) mAb

Recombinant human CD279(PD-1)-muIg

Recombinant human CD274(PD-L1)-muIg

Recombinant human CD273(PD-L2)-muIg