Interfering with the CD279(PD-1) – CD274(PD-L1) axis has shown great promise in restoring anti-cancer T cell function. This Pittsburgh research group has used a similar approach in a mouse HSV-1 model to improve T cell mediated viral clearance from the immunologically sequestered cornea.
“PD-L1/B7-H1 Inhibits Viral Clearance by Macrophages in HSV-1–Infected Corneas” Sohyun Jeon, Alexander M. Rowe, Kate L. Carroll, Stephen A. K. Harvey and Robert L. Hendricks J Immunol June 1, 2018, 200 (11) 3711-3719; DOI: https://doi.org/10.4049/jimmunol.1700417
Related Ancell Products
Recombinant human CD279(PD-1)-muIg