Glioma treatment using Checkpoint inhibition + CAR looks promising!

CD133 specific CAR-macrophages created in situ using NanoPorter hydrogel in combination with CD47 checkpoint blocking antibody improves post operative Glioblastoma survival in a humanized mouse model “Intracavity generation of glioma stem cell–specific CAR macrophages primes locoregional immunity for postoperative glioblastoma therapy” Chen Chen, Xinyi Jiang, et al. Science Translational Medicine 14: 656 DOI: 10.1126/scitranslmed.abn1128 CD47 …

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Emerging importance of Siglecs in assisting tumor evasion of immune surveillance

Siglecs and their ligands are expressed by many tumors, and can serve to down-regulate immune response. REVIEW article: “The intriguing roles of Siglec family members in the tumor microenvironment” Kui-Ying Jiang, Ling Wang, et al. (2022) Biomarker Research 10: 22 PMID: 35418152 “Molecular Mechanism of Tumor Cell Immune Escape Mediated by CD24/Siglec-10” Shan-Shan Yin, Feng-Hou Gao …

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ANC28.1 mAb as a stimulating agent in a Cytokine Release Assay for assessment of preclinical safety

“Development of a flow cytometry-based potency assay for prediction of cytokine storms induced by biosimilar monoclonal antibodies” Natasha Helleberg Madsen, Monika Gad, Jesper Larsen. (Feb 5, 2022) J Immunol Methods 502: 113231. https://doi.org/10.10 PBMC were stimulated with immobilized ANC28.1, CD28.1 and muromonab CD3. Assessed Cytokines and levels of Activation molecules by flow could determine the …

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Ancell reagents and personnel involved in a new SARS-Co-V2 breast milk antibody study

“Increase in SARS-CoV-2 RBD-specific IgA and IgG Antibodies in Breast Milk from Lactating Women Following the COVID-19 Booster Vaccination” Andrea M Henle MedRxiv (Feb 24, 2022 Pre print) doi: https://doi.org/10.1101/2022.02.23.22271414 Related Ancell products: anti-human IgA monoclonal antibody anti-human IgG monoclonal antibody Recombinant SARS-CO-V2-RBD-His protein #581-820 (Inquire)

Exosomes increase PD-L1 expression and induce tolerance to NIMA

A University of WI Madison research group used Ancell antibodies to analyze exosomes involved in the induction of tolerance to non-inherited maternal antigens(NIMA). This could have implications for allogeneic graft tolerance./ “Cross-Decoration of Dendritic Cells by Non-Inherited Maternal Antigen-Containing Extracellular Vesicles: Potential Mechanism for PD-L1-Based Tolerance in Cord Blood and Organ Transplantation”Diego A. Lema, A …

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Ancell anti-CD63 antibody used to capture Tumor Extracellular Vesicles from Colorectal Cancer patient plasma in a high throughput device

The device captures EV from plasma and analyzes clinically relevant tumour biomarkers (EGFR, EpCAM, CD24 and GPA33) of colorectal cancer (CRC). The results were predictive of disease severity and prognosis for the test subjects. “An integrated magneto-electrochemical device for the rapid profiling of tumour extracellular vesicles from blood plasma” Jongmin Park, Hakho Lee, et al. …

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Neutrophil Trogocytosis blocked by Ancell anti-CD18 mAb and F(ab’)2 reagents in a CD47-SIRPa checkpoint disrupted model

The use of Neutrophils from FERMT3 patients elucidated the requirement of kindlen3-CD18 interaction for synapse formation and trogocytosis of antibody opsinized SIRPa-CD47 checkpoint disruped cancer cells in vitro. “Kindlin3-Dependent CD11b/CD18-Integrin Activation IsRequired for Potentiation of Neutrophil Cytotoxicity byCD47–SIRPa Checkpoint Disruption” Panagiota Bouti, Timo K. van den Berg, et al. (Dec 2020) Cancer Immunology Research Priority …

Neutrophil Trogocytosis blocked by Ancell anti-CD18 mAb and F(ab’)2 reagents in a CD47-SIRPa checkpoint disrupted model Read More »