Thymulin levels in mice and humans decrease with age as levels of chronic myeloid inflammationincrease.Compared to aged mice, levels of pro inflammatory cytokines IL-1a, IL-1b, IL-6 and TNFa and were decreased in bone marrow chimeric mice. This was also observed in old mice treated with Thymulin peptide. A similar effect was observed in human PBMC

This Chinese research team identified a link between CD55 downregulation on CD4+ T cells and aberrant T cell activation. This effect will likely prove to be useful to assess prognosis of Rheumatoid arthritis and other T cell driven autoimmune disorders. “CD55 downregulation identifies a pathogenic CD4+ T cell axis linked to p38 MAPK signaling in

Swiss Researchers developed and sequenced 4 mAbs vs Birch pollen (Bet v1 antigen)and derived Fv constructs to create Chimeric Antigen Receptor cells using murine primary Treg. These were tested in vitro and in a Mouse AAI model to downregulate inflammation. “Chimeric allergen receptor regulatory T cells suppress birch pollen allergic airway inflammation”Ana Alcaraz-Serna , Yannick

Administration of iNKT-DC complexes to mice with a xenograft B cell lymphoma stimulated efficient CD8+ T cell-mediated tumor regression. “CD8+ T-cell Antitumor Immunity via Human iNKT–DC Conjugates” Dana C. Baiu, Jenny E. Gumperz, et al. Cancer Immunol Res (2026) 14 (2): 318–334. PMID: 41236542 PMCID: PMC12716482 DOI: 10.1158/2326-6066.CIR-25-0454 Related Ancell Products anti-CD69 mAb

H pylori infection leads to upregulation of COX2 and CD38 on mast cells, which suppress CD8+ T cell cytotoxicity through increased levels of PGE2 and adenosine. “Activated CD38+ mast cells promote gastric cancer progression by suppressing CD8+ T cell cytotoxic activity through adenosine metabolism” Jiabao Zhao, Xuehui Hong, et al. (2026 Jan 22) Cell Rep

This Danish research group utilized Ancell anti-tetraspanin biotinylated mAbs to detect purified and unpurified EVs from ischemic stroke patient plasma captured on microarray. “Direct Profiling of Extracellular Vesicle Surface Markers in Plasma: A Proof-of-Concept Study” Lee-Ann Clegg, Malene Möller Jörgensen, et al. Biol Cell 2025 Dec;117(12):e70047. doi: 10.1111/boc.70047 PMID: 41420477 Related Ancell Products anti-CD9 anti-CD63

OX40(CD134) expression on CAR T cell surface improves anti-tumor activity in a mouse model. “OX40–heparan sulfate binding facilitates CAR T cell penetration into solid tumors in mice” Huihui Zhang, Xuanming Yang, et al. (18 June 2025) Science Translational Medicine 17(803):eadr2151. doi: 10.1126/scitranslmed.adr2151. Epub 2025 Jun 18. PMID: 405 Related Ancell Products anti-human CD134(OX40) mAb anti-human

Authors review utilization of various types of humanized mice to study human immunological mechanisms. Challenges include engineering humanized populations of Neutrophils, Red Blood Cells, Hepatocytes, and resident Skin macrophages. They cite and recommend multi-omic canonical correlations of human vs humanized mouse biomarkers to assess the utility of these technologies. “Engineering Mice to Study Human Immunity”

Hyper IgM Syndrome is an immune disorder usuallycaused by an X-linked mutation in the CD40L(CD154) gene. In this study,the authors were able to discern an altered CD40L phenotypein a patient. While anti-CD40L mAbs still recognized the molecule in flow cytometry, a recombinant CD40 reagent failed to bind. Genetic analysis determined this to be caused by

IgA Nephropathy is one of the leading causes of kidney failure worldwide. It is caused by production of IgA1 antibodies lacking galactose in their o-Glycan regions, which cause them to be auto antigenic and can lead to protein aggregates. Traditional treatments have been limited to kidney care lifestyle modification and high-dose long term glucocordicosteroids. More