CF33-hNIS, a modified vaccinia (small pox) virus will be tested by IV or Intratumoral injection, with or without PD-1 inhibitor, pembrolizumab in patients with advanced or metastaic solid tumors. Link to Medical News Today Article Link to Clinical Trial Link to a Background article Ancell human PD-1 related Research Products CD279(PD-1) CD274 (PD-L1) CD273 (PD-L2)
“Development of a flow cytometry-based potency assay for prediction of cytokine storms induced by biosimilar monoclonal antibodies” Natasha Helleberg Madsen, Monika Gad, Jesper Larsen. (Feb 5, 2022) J Immunol Methods 502: 113231. https://doi.org/10.10 PBMC were stimulated with immobilized ANC28.1, CD28.1 and muromonab CD3. Assessed Cytokines and levels of Activation molecules by flow could determine the …
“Increase in SARS-CoV-2 RBD-specific IgA and IgG Antibodies in Breast Milk from Lactating Women Following the COVID-19 Booster Vaccination” Andrea M Henle MedRxiv (Feb 24, 2022 Pre print) doi: https://doi.org/10.1101/2022.02.23.22271414 Related Ancell products: anti-human IgA monoclonal antibody anti-human IgG monoclonal antibody Recombinant SARS-CO-V2-RBD-His protein #581-820 (Inquire)
A University of WI Madison research group used Ancell antibodies to analyze exosomes involved in the induction of tolerance to non-inherited maternal antigens(NIMA). This could have implications for allogeneic graft tolerance./ “Cross-Decoration of Dendritic Cells by Non-Inherited Maternal Antigen-Containing Extracellular Vesicles: Potential Mechanism for PD-L1-Based Tolerance in Cord Blood and Organ Transplantation”Diego A. Lema, A …
Exosomes increase PD-L1 expression and induce tolerance to NIMA Read More »
In a Mayo Clinic study, the blood from 19 T-ALL patients were compared to 24 normal samples using a flow cytometric panel. While the normal samples all showed a “characteristic and reproducible” pattern of cellsurface expressed CD3 and TRBC1 positivity, the leukemic samples were either almost entirely TRCB1 positive or almost entirely negative, indicating T …
Anti-TRBC1 (TCR Cb1) antibody indicates clonality in T-ALL Read More »
Ancell anti-CD26 and anti-CD36 biotinylated antibodies used to capture HIV Virions from CSF of patients undergoing ARV treatment. The markers on sorted virions correlate with host cellular origin. “T cell derived HIV-1 is present in the CSF in the face of suppressive anti-retroviral therapy” G Lustig, A Sigal, et al. (Sep 2021) PLoS Pathog 17(9): …
The device captures EV from plasma and analyzes clinically relevant tumour biomarkers (EGFR, EpCAM, CD24 and GPA33) of colorectal cancer (CRC). The results were predictive of disease severity and prognosis for the test subjects. “An integrated magneto-electrochemical device for the rapid profiling of tumour extracellular vesicles from blood plasma” Jongmin Park, Hakho Lee, et al. …
The use of Neutrophils from FERMT3 patients elucidated the requirement of kindlen3-CD18 interaction for synapse formation and trogocytosis of antibody opsinized SIRPa-CD47 checkpoint disruped cancer cells in vitro. “Kindlin3-Dependent CD11b/CD18-Integrin Activation IsRequired for Potentiation of Neutrophil Cytotoxicity byCD47–SIRPa Checkpoint Disruption” Panagiota Bouti, Timo K. van den Berg, et al. (Dec 2020) Cancer Immunology Research Priority …
“Flow cytometric evaluation of TRBC1 expression in tissue specimens and body fluids is a novel and specific method for assessment of T-cell clonality and diagnosis of T-cell neoplasms” H Berg, H Olteanu, et al. (May 2021) Clinical Cytometry 100(3): 361-369. https://doi.org/10.1002/cyto.b.21881 Ancell anti-human TRCB1 (Clone JOVI-1) reagents: 101-020 Purified (with Preservative) 101-820 Purified …
Blockade of CD155/TIGIT signaling in conjunction with PD-1 blockade and CD40 agonism restores T cell function in mouse pancreatic cancer model “The CD155/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancer” Freed-Pastor WA, Tyler Jacks, et al. (July 2021) Cancer Cell S1535-6108(21)00384-6. doi: 10.1016/j.ccell.2021.07.007 Relevant Ancell Immunology tools anti-human TIGIT mAb Recombinant human …
TIGIT blockade restores T cell function in pancreatic cancer model Read More »
