Anti-TRBC1 (TCR Cb1) antibody indicates clonality in T-ALL
In a Mayo Clinic study, the blood from 19 T-ALL patients were compared to 24 normal samples using a flow cytometric panel. While the normal samples all showed a “characteristic and reproducible” pattern of cellsurface expressed CD3 and TRBC1 positivity, the leukemic samples were either almost entirely TRCB1 positive or almost entirely negative, indicating T …
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