The use of Neutrophils from FERMT3 patients elucidated the requirement of kindlen3-CD18 interaction for synapse formation and trogocytosis of antibody opsinized SIRPa-CD47 checkpoint disruped cancer cells in vitro. “Kindlin3-Dependent CD11b/CD18-Integrin Activation IsRequired for Potentiation of Neutrophil Cytotoxicity byCD47–SIRPa Checkpoint Disruption” Panagiota Bouti, Timo K. van den Berg, et al. (Dec 2020) Cancer Immunology Research Priority […]

  “Flow cytometric evaluation of TRBC1 expression in tissue specimens and body fluids is a novel and specific method for assessment of T-cell clonality and diagnosis of T-cell neoplasms”   H Berg, H Olteanu, et al. (May 2021) Clinical Cytometry 100(3): 361-369. https://doi.org/10.1002/cyto.b.21881   Ancell anti-human TRCB1 (Clone JOVI-1) reagents: 101-020 Purified (with Preservative) 101-820 Purified

Blockade of CD155/TIGIT signaling in conjunction with PD-1 blockade and CD40 agonism restores T cell function in mouse pancreatic cancer model “The CD155/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancer” Freed-Pastor WA, Tyler Jacks, et al. (July 2021) Cancer Cell S1535-6108(21)00384-6. doi: 10.1016/j.ccell.2021.07.007 Relevant Ancell Immunology tools anti-human TIGIT mAb Recombinant human

Highly active recombinant CD304-muIg protein now available from Ancell! Ancell HEK cell derived CD304-muIg binds in EIA to immobilized VEGF165. CD304 references “CD304/neuropilin-1 is a very useful and dependable marker for the measurable residual disease assessment of B-cell precursor acute lymphoblastic leukemia” Pratyusha Gudapati Prashant R Tembhare , et al. (2020 Jul) Cytometry B Clin Cytom.

Researchers from University of Zurich and California Institute of Technology utilize an Adenovirus 5 virion with anti-HER2 TZB antibody (Herceptin) expressing payload to treat orthotopic human HER2 positive tumors in mice. Virion was modified with bispecific multivalent DARPin with external specificity to HER2 receptor, and shielded with scFV directed to coagulation factor X-binding sites on

A Danish study1 in JI showed that the serum titer of anti-SARS-CoV-2 IgG, IgA and IgM antibodies in COVID-19 patients correlated with disease severity. “…Abs toward SARS-CoV-2 represent a double-edged sword…” In a Turkish study2 (also published in JI) of recovered COVID-19 patients, 20% did not have significant levels of SARS-CoV-2 neutralizing antibodies. This cohort

Johns Hopkins researchers used mouse ex vivo K14+ breast cancer organoid model to study the effect of tumor exposure to NK cells. teNK cells were found to lose cytotoxicity and to promote metastesis. This effect could be overcome by blockade with anti-TIGIT or anti-KRLG antibodies, both of which are promising immune checkpoints for Cancer therapy.

A 195-participant-study found that this drug prolonged survival and lessened inflammation in patients with severe Covid-19. “Repurposed Tocilizumab in Patients with Severe COVID-19” Jianbo Tian, Huilan Zhang , et al. (Dec 9, 2020) J Immunol ji2000981. doi: 10.4049/jimmunol.2000981.

Nasal spray contains a cholesterol linked lipopeptide which binds to the S2 region of SARS-CO-V2 spike in proximity to the HR2 domain. This prevents it from contracting towards the HR1 domain and therby inhibits cell fusion and infection. “Intranasal fusion inhibitory lipopeptide prevents direct contact SARS-CoV-2 transmission in ferrets” Rory D. de Vries, Matteo Porotto,

anti-CD137 (4-1BB) agonistic mAb alone improves tumor infiltration and anti-tumor response in mice. Intratumoral Activation of 41BB Costimulatory Signals Enhances CD8 T Cell Expansion and Modulates Tumor-Infiltrating Myeloid Cells” Patrick Innamarato, Shari Pilon-Thomas, et al. (Oct 2020) J Immunol October 5, 2020, ji2000759; DOI: https://doi.org/10.4049/jimmunol.2000759. Related Ancell Products anti-human CD137 mAb clone 4B4-1