Swiss Researchers developed and sequenced 4 mAbs vs Birch pollen (Bet v1 antigen)and derived Fv constructs to create Chimeric Antigen Receptor cells using murine primary Treg. These were tested in vitro and in a Mouse AAI model to downregulate inflammation.
“Chimeric allergen receptor regulatory T cells suppress birch pollen allergic airway inflammation”Ana Alcaraz-Serna , Yannick D. Muller, et al. J Exp Med (2026) 223 (8): e20252201.
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