“PD-1 Blockade Promotes Epitope Spreading in Anti-cnacer CD8+ T cell Reponses by Preventing Fratricidal Death of Subdominant Clones To Relieve Immunodomination” Arash Memarnejadian, S M Mansour Haeryfar, et al. (Nov 2017) J Immunol 199(9): 3348-59. https://doi.org/10.4049/jimmunol.1700643. PMID: 28939757
Often over time, an anti-Cancer immune response narrows into a few dominant (high affinity) CD8+ T cell clones. This Canadian Research group showed that blockading CD279 (PD-1) restored function of a wider array of sub dominant (lower affinity) anti-Cancer CD8+ T cell clones in a mouse in vivo model.
Related Ancell Research Products
anti-human CD279(PD-1) mAb
anti-human CD274 (PD-L1) mAb
anti-human CD273 (PD-L2) mAb
Recombinant human CD279-muIg
Recombinant human CD274-muIg
Recombinant human CD273-muIg