ANC28.1 mAb used as a Control in a Modified Chandler-loop model developed to screen and assess drug toxicityBy room34 / March 21, 2018 ANC28.1 mAb used as a Control in a Modified Chandler-loop model developed to screen and assess drug toxicity This system could potentially prevent disastrous clinical human trials like the TGN1412 (anti-CD28) one. “Extracorporeal human whole blood in motion as a tool to predict first-infusion reactions and mechanism-of-action of immunotherapeutics” E A K Fletcher, S M Mangsbo, et al. (Jan 2018) International Immunopharmacology 54: 1-11. Related Ancell Research Products anti-human CD28 Superagonist mAb clone: ANC28.1 anti-human CD3 Agonist mAb clone UCHT1
