anti-CD30 Allophycocyanin

Human CD30 is a member of the tumor necrosis factor (TNF) receptor family and is expressed on mitogen activated B and T cells.

Isotype: Murine IgG2b Kappa

Immunogen: Human YT lymphoma cells

Specificity: Antibody AC10 recognizes the CD30 molecule of about 120 kd (1, 2) and blocks the CD30 / CD153 interaction.  It binds to epitope CRD1-3 of the CD30 molecule(7).  Antibody AC10 has been found to inhibit growth of Hodgkins Lymphoma cell line in vitro (5).  Clone AC10 was used as the basis for the drug Brentuximab(6).

References:

1.  M A Bowen, E R Podack, et al. (1993)  J Immunol  151: 5896-5906.  PMID: 8245437

2.  Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 1115-1122.

3.  B. Falini, et al, (1995) Blood  85: 1-14.

4.  K. Agematsu, et al, (1995) J Immunol  154: 3627-3635.

5.  AF Wahl, JA Francisco, et al. Canc Res (2002) 62(13): 3736-3742. PMID: 12097283

6. Marelia Barreca, et al. Explor Target Antitumor Ther. 2022; 3(6): 763–794. 2022 Dec 26. doi: 10.37349/etat.2022.00112 PMID: 36654819

7. H. Akiba, S. Nagata, et al. (Jan 2025) Antibody Therapeutics 8(1): 56-67.  https://doi.org/10.1093/abt/tbaf002. PMID: 39958564

USD $375
In cart: 0
= $375
Catalog #:
179-060
Form:
APC
Size:
120 tests
Alternate Name:
Ki-1
Clone:
AC10
Applications:
FC

Application Key

FC
Flow Cytometry
WB
Western blot
EIA
Enzyme Immunoassay
IHC
Immunohistochemistry
ICC
Immunocytochemistry
FPS
Fixed paraffin section
PS
Paraffin section
IP
Immunoprecipitation
FX
Fixed cells or tissues

Applications indicated have been either tested in-house or reported. Products may be functional for applications not indicated.

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