Isotype: Murine IgG2b Kappa
Immunogen: Human YT lymphoma cells
Specificity: Antibody AC10 recognizes the CD30 molecule of about 120 kd (1, 2) and blocks the CD30 / CD153 interaction. Antibody AC10 has been found to inhibit growth of Hodgkins Lymphoma cell line in vitro (5). Clone AC10 was used as the basis for the drug Brentuximab(6).
2. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 1115-1122.
3. B. Falini, et al, (1995) Blood 85: 1-14.
4. K. Agematsu, et al, (1995) J Immunol 154: 3627-3635.