Transplanted islet cells were biochemically modified to protect their own long term engraftment in a mouse pancreas.  These cells have the super-ability to cause apoptosis to occur in the infiltrating pathogenic T cells.  This is a novel approach to diabetes treatment!  ”Pancreatic Islets Engineered with SA-FasL Protein Establish Robust Localized Tolerance by Inducing Regulatory T […]

“Abrogation of CD30 and OX40 signals prevents autoimmune disease in FoxP3-deficient mice”  FM Gaspal, PJL Lane, et al. (2011) JEM 208(8): 1579-1584.  Ancell related products Blocking anti-human CD30 mAb Recombinant  human CD134 and CD252 Proteins Anti-human CD134 and CD252 mAbs

Ancell and Heliocyte are proud to sponsor travel and poster award stipends for Great Lakes International Imaging and Flow Cytometry Association 2011 conference in Oconomowoc, WI!

S. Alice Long and Jane H. Buckner “CD4+ FOXP3+ T Regulatory cells in Human Autoimmunity: More than a Numbers Game” J Immunol (2011) 187:2061-2066

Abrogation of CD30 and OX40 signals prevents autoimmune disease in FoxP3-deficient mice.  Gaspal F.M., P.J.L Lane, et al. (2011) JEM 208(8): 1579-1584.   Ancell Products anti-human CD30 antibody products anti-human CD134(OX40) antibody products anti-human CD252(OX40L) antibody products Recombinant human CD134(OX40) Recombinant human CD252(OX40L)

New anti-Mouse CD4 PE-Cy7 conjugate available now! Watch for more PE-Cy7 conjugates available soon.

Ancell announces partnership with HelioCyte to provide cutting edge Flow Cytometry products! Watch for new products designed to simplify and improve your Flow research! Twitter account:  Heliocyte

Improved multi-color staining of Mouse tissues Anti-Mouse CD4 (clone GK1.5)/DyLight350*  conjugate now available!   Catalog #704-350 DyLight350* is excitable by Near-UV laser Amax 353, and emits in the blue range, Emax 432nm. Look for more DyLight350 conjugates available soon!

Engagement of CD134(OX40) by its Ligand (CD252) induces an intracellular signaling complex which  includes PKB, and PI3K, and requires TRAF2. Takanori S, H Choi, M Croft. (2011) J Immunol 186(6):3547-3555.   Ancell Products: Recombinant human CD134-muIg Fusion protein Recombinant human CD252(OX40)-muCD8 Monoclonal anti-human CD134(OX40) Monoclonal anti-human CD252(OX40L)  

In mice, use of CD28 superagonist has been shown to increase the % of Treg cells, and protect from Rheumatoid Arthritis mediated bone destruction.Marlo M Zaiss, Jean-Pierre David, et al. (2010) J Immunol 184: 7238-7246. Ancell anti-CD28 antibody clone ANC28.1/5D10 has been characterized as a superagonist. This mAb has been found to be capable of stimulating