Cutting Edge: IL-2 Signals Determine the Degree of TCR Signaling Necessary To Support Regulatory T Cell Proliferation In Vivo. Zou T, Kambayashi T. et al. J Immunol. 2012 Jul 1;189(1):28-32. It has been thought that proliferation of T regulatory cells in vivo was dependent on signaling from T cell receptor –MHC Class II interaction.  Zou […]

“Human Th17 Cells Express High Levels of Enzymatically active Dipeptidylpeptidase IV (CD26)” Bengsch B, R Thimme, et al, (2012) J Immunol 188(11): 5438-5447. In transwell assays, CD26(bright) Th17 cells inhibited chemotaxis of CXCR4+ Th1 T cells towards CXCL12.   CD26 appears to be an interesting and useful marker for Th17 autoimmunity. Ancell anti-CD26 reagents (clone 202.36):

A link found between autoimmune antibody specificity to Citrullinated Protein and development of Rheumatoid Arthritis. “Production of Autoantibodies against Citrullinated Antigens/Peptides by Human B Cells”  Maria F. Bellatin, Peter Stastny, et al. (2012) J Immunol 188(7): 3542-3550 Ancell has a large selection of Biotinylated anti-human monoclonal antibodies which would be useful for sorting and/or identifying

Levels of the proinflammatory leptin correlated inversely with expansion of CD25+CD4+Foxp3+ T regulatory cells in a Systemic Lupus Erythematosus mouse model (NZB/W).  This could lead to a leptin-based immunotherapy.”Cutting Edge: Fasting Induced Hypoleptinemia Expands Functional Regulatory T cells in Systemic Lupus Erythematosus”Yaoyang Liu, Yiyun Yu, Antonio La Cava, (2012) J Immunol 188: 2070-2073.  Relevant Ancell

 Increased Expression of CD229(SLAMF3) and CD352(SLAMF6)  in SLE T Lymphocytes Promotes Th17 Differentiation Chatterjee M., G.C. Tsokos, et al. (2012) J Immunol 188: 1206-1212.

Transplanted islet cells were biochemically modified to protect their own long term engraftment in a mouse pancreas.  These cells have the super-ability to cause apoptosis to occur in the infiltrating pathogenic T cells.  This is a novel approach to diabetes treatment!  ”Pancreatic Islets Engineered with SA-FasL Protein Establish Robust Localized Tolerance by Inducing Regulatory T

“Abrogation of CD30 and OX40 signals prevents autoimmune disease in FoxP3-deficient mice”  FM Gaspal, PJL Lane, et al. (2011) JEM 208(8): 1579-1584.  Ancell related products Blocking anti-human CD30 mAb Recombinant  human CD134 and CD252 Proteins Anti-human CD134 and CD252 mAbs

Ancell and Heliocyte are proud to sponsor travel and poster award stipends for Great Lakes International Imaging and Flow Cytometry Association 2011 conference in Oconomowoc, WI!

S. Alice Long and Jane H. Buckner “CD4+ FOXP3+ T Regulatory cells in Human Autoimmunity: More than a Numbers Game” J Immunol (2011) 187:2061-2066

Abrogation of CD30 and OX40 signals prevents autoimmune disease in FoxP3-deficient mice.  Gaspal F.M., P.J.L Lane, et al. (2011) JEM 208(8): 1579-1584.   Ancell Products anti-human CD30 antibody products anti-human CD134(OX40) antibody products anti-human CD252(OX40L) antibody products Recombinant human CD134(OX40) Recombinant human CD252(OX40L)