M. Mkrtichyan, S.N. Khleif, et al. (2012) J Immunol 189(5): 2338-2347.
Engagement of CD279(PD-1) by recombinant CD273 (B7-DC)-muIg enhances effect of anti-tumor vaccine in mice.
Two proposed mechanisms by which this recombinant protein may augment anti tumor vaccine effect: 1) It inhibits proliferation of PD-1high CD4+ T cells, thereby reducing the number of T reg cells within the tumor. 2) It decreases the number of exhausted CD8+ T cells which leads to a better tumor specific cytotoxic response.
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