“B7-DC-Ig Enhances Vaccine Effect by a Novel Mechanism Dependent on PD-1 Expression level on T Cell Subsets” M. Mkrtichyan, S.N. Khleif, et al. (2012) J Immunol 189(5): 2338-2347. Engagement of CD279(PD-1) by recombinant CD273 (B7-DC)-muIg enhances effect of anti-tumor vaccine in mice. Two proposed mechanisms by which this recombinant protein may augment anti tumor […]
PD-1 engagement enhances anti-tumor vaccine in mice Read More »
Cutting Edge: IL-2 Signals Determine the Degree of TCR Signaling Necessary To Support Regulatory T Cell Proliferation In Vivo. Zou T, Kambayashi T. et al. J Immunol. 2012 Jul 1;189(1):28-32. It has been thought that proliferation of T regulatory cells in vivo was dependent on signaling from T cell receptor –MHC Class II interaction. Zou
In vivo Treg proliferation from IL-2 signaling alone Read More »
“Human Th17 Cells Express High Levels of Enzymatically active Dipeptidylpeptidase IV (CD26)” Bengsch B, R Thimme, et al, (2012) J Immunol 188(11): 5438-5447. In transwell assays, CD26(bright) Th17 cells inhibited chemotaxis of CXCR4+ Th1 T cells towards CXCL12. CD26 appears to be an interesting and useful marker for Th17 autoimmunity. Ancell anti-CD26 reagents (clone 202.36):
CD4+ CD26(bright) Human T cells display Th17 phenotype Read More »
A link found between autoimmune antibody specificity to Citrullinated Protein and development of Rheumatoid Arthritis. “Production of Autoantibodies against Citrullinated Antigens/Peptides by Human B Cells” Maria F. Bellatin, Peter Stastny, et al. (2012) J Immunol 188(7): 3542-3550 Ancell has a large selection of Biotinylated anti-human monoclonal antibodies which would be useful for sorting and/or identifying
Citrullinated Protein and RA Read More »
Levels of the proinflammatory leptin correlated inversely with expansion of CD25+CD4+Foxp3+ T regulatory cells in a Systemic Lupus Erythematosus mouse model (NZB/W). This could lead to a leptin-based immunotherapy.”Cutting Edge: Fasting Induced Hypoleptinemia Expands Functional Regulatory T cells in Systemic Lupus Erythematosus”Yaoyang Liu, Yiyun Yu, Antonio La Cava, (2012) J Immunol 188: 2070-2073. Relevant Ancell
Leptin affects Treg populations in SLE Read More »
Increased Expression of CD229(SLAMF3) and CD352(SLAMF6) in SLE T Lymphocytes Promotes Th17 Differentiation Chatterjee M., G.C. Tsokos, et al. (2012) J Immunol 188: 1206-1212.
SLAM receptors infulence TH17 Differentialtion in SLE Read More »
Transplanted islet cells were biochemically modified to protect their own long term engraftment in a mouse pancreas. These cells have the super-ability to cause apoptosis to occur in the infiltrating pathogenic T cells. This is a novel approach to diabetes treatment! ”Pancreatic Islets Engineered with SA-FasL Protein Establish Robust Localized Tolerance by Inducing Regulatory T
Killer Islet Cells! Read More »
“Abrogation of CD30 and OX40 signals prevents autoimmune disease in FoxP3-deficient mice” FM Gaspal, PJL Lane, et al. (2011) JEM 208(8): 1579-1584. Ancell related products Blocking anti-human CD30 mAb Recombinant human CD134 and CD252 Proteins Anti-human CD134 and CD252 mAbs
Ancell and Heliocyte are proud to sponsor travel and poster award stipends for Great Lakes International Imaging and Flow Cytometry Association 2011 conference in Oconomowoc, WI!
Travel Awards for GLIIFCA 2011 Read More »
S. Alice Long and Jane H. Buckner “CD4+ FOXP3+ T Regulatory cells in Human Autoimmunity: More than a Numbers Game” J Immunol (2011) 187:2061-2066
