Killer Islet Cells!

Transplanted islet cells were biochemically modified to protect their own long term engraftment in a mouse pancreas.  These cells have the super-ability to cause apoptosis to occur in the infiltrating pathogenic T cells.  This is a novel approach to diabetes treatment! 

”Pancreatic Islets Engineered with SA-FasL Protein Establish Robust Localized Tolerance by Inducing Regulatory T Cells in Mice” E.S. Yolcu, H. Shirwan, et al. (2011) J Immunol 187: 5901-5909