anti-CD45RA Purified (Preservative-free)

Human CD45RA is expressed on all cells of hematopoietic origin, except erythrocytes.  CD45RA is a transmembrane tyrosine phosphate which can exist in at least nine different isoforms resulting from tissue-specific alternative RNA splicing of exons 4-7 of a single gene coding for the various N-terminal peptide segments.  The CD45RA isoform predominates on naive/resting T cells and medullary thymocytes.

Isotype: Murine IgG2a

Immunogen: Stimulated human leukocytes

Specificity: Antibody 158.4D3 recognizes all CD45 molecules containing the A region exon (1,2).

References:

1.  Leukocyte Typing III (A.J. McMichael, et al, eds.)  Oxford University Press, Oxford, (1987) p. 788-817.

2.  A. Gaya, et al, (1990) Intl Immunol  2:685-689.

3.  I.S. Trowbridge & M.L. Thomas, (1994) Annu Rev Immunol  12: 85-116.