Human CD45RA is expressed on all cells of hematopoietic origin, except erythrocytes. CD45RA is a transmembrane tyrosine phosphate which can exist in at least nine different isoforms resulting from tissue-specific alternative RNA splicing of exons 4-7 of a single gene coding for the various N-terminal peptide segments. The CD45RA isoform predominates on naive/resting T cells and medullary thymocytes.
Isotype: Murine IgG2a
Immunogen: Stimulated human leukocytes
Specificity: Antibody 158.4D3 recognizes all CD45 molecules containing the A region exon (1,2).
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