anti-CD45RA R-PE Conjugate
Human CD45RA is expressed on all cells of hematopoietic origin, except erythrocytes. CD45RA is a transmembrane tyrosine phosphate which can exist in at least nine different isoforms resulting from tissue-specific alternative RNA splicing of exons 4-7 of a single gene coding for the various N-terminal peptide segments. The CD45RA isoform predominates on naive/resting T cells and medullary thymocytes.
Isotype: Murine IgG2a
Immunogen: Stimulated human leukocytes
Specificity: Antibody 158.4D3 recognizes all CD45 molecules containing the A region exon (1,2).
1. Leukocyte Typing III (A.J. McMichael, et al, eds.) Oxford University Press, Oxford, (1987) p. 788-817.
2. A. Gaya, et al, (1990) Intl Immunol 2:685-689.
3. I.S. Trowbridge & M.L. Thomas, (1994) Annu Rev Immunol 12: 85-116.