Human CD106 is an endothelial adhesion molecule that binds to alpha 4 beta 1 & alpha 4 beta 7 integrins (VLA-4) and promotes adhesion of lymphocytes, monocytes, eosinophils and basophils. CD106 is also found on follicular dendritic cells, interdigitating recticulum cells and Kupffer cells (3).
Isotype: Murine IgG1
Immunogen: Human endothelial cells
Specificity: Antibody 1.G11B1 recognizes the an extracellular epitope of the human VCAM-1 molecule (CD106) which is involved with leukocyte adhesion (1, 2,3). It has been reported to be cross reactive with porcine CD106.
Functional Application: Antibody 1.G11B1 binds to an epitope located within the first three n-terminal loops of CD106. This mAb blocks lymphocyte(3,12) and eosinophil (6) adhesion to CD106. It has been reported to work in FACS(10, 11), IHC (frozen section) and Western blot(8).
2) M.H. Thornhill, D.O. Haskard, (1991) J Immunol 146: 592-598.
3) Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 1764-1767.
4) M. Nagata, et al, (1995) J Immunol 155: 2194-2202.
5) H.E. Chuluyan, et al, (1995) J Immunol 155: 3135-3144.