anti-CD95 FITC Conjugate

Human CD95 (APO-1/FAS) is a type I cell surface glycoprotein that is strongly upregulated on activated T cells, B cells, NK cells and thymocytes (1).  CD95 plays an important role in programmed cell death or apoptosis (2).  Apoptosis appears to be a mechanism for regulating the immune response (3, 4).

Isotype: Murine IgG1

Immunogen: Human soluble FAS with the transmembrane region deleted

Specificity: Antibody ANC95.1 reacts with cell surface expressed CD95.  This mAb does not induce apoptosis.

 

References:

1.   Leukocyte Typing V (S.F. Schlossman, et al, eds.)  Oxford University Press, Oxford  (1995) p. 1142-1148.

2.  S. Nagata & P. Golstein, (1995) Science  267: 1449-1456.

3.  S. Nagata & T. Suda, (1995) Immunol Today  16: 39-43.

4.  D.H. Lynch, F. Ramsdell & M.R. Alderson, (1995) Immunol Today  16: 569-574.

5.  H Wajant, (2003) Essays Biochem 39:53-71.

6. M Akdis, C A Akdis, et al. (2003) FASEB J 17(9): 1026-1035.

USD $235.00
In cart: 0
= $235.00
Catalog #:
316-040
Form:
FITC
Size:
120 tests
Alternate Name:
APO-1, FAS
Clone:
ANC95.1/E2
Applications:
EIA, FC, IHC(6)

Application Key

FC
Flow Cytometry
WB
Western blot
EIA
Enzyme Immunoassay
IHC
Immunohistochemistry
ICC
Immunocytochemistry
FPS
Fixed paraffin section
PS
Paraffin section
IP
Immunoprecipitation
FX
Fixed cells or tissues

Applications indicated have been either tested in-house or reported. Products may be functional for applications not indicated.

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