Human CD95 (APO-1/FAS) is a type I cell surface glycoprotein that is strongly upregulated on activated T cells, B cells, NK cells and thymocytes (1). CD95 plays an important role in programmed cell death or apoptosis (2). Apoptosis appears to be a mechanism for regulating the immune response (3, 4).
Isotype: Murine IgG1
Immunogen: Human soluble FAS with the transmembrane region deleted
Specificity: Antibody ANC95.1 reacts with cell surface expressed CD95. This mAb does not induce apoptosis.
1. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford (1995) p. 1142-1148.
2. S. Nagata & P. Golstein, (1995) Science 267: 1449-1456.
3. S. Nagata & T. Suda, (1995) Immunol Today 16: 39-43.
4. D.H. Lynch, F. Ramsdell & M.R. Alderson, (1995) Immunol Today 16: 569-574.
5. H Wajant, (2003) Essays Biochem 39:53-71.