anti-CD86 R-PE Conjugate
Human CD86 (B7-2) is a costimulating ligand for CD28 and CTLA-4. CD86 is expressed on activated B cells and blood monocytes (3).
Isotype: Murine IgG1
Immunogen: ARH-77 (B-lymphoblastoid cell line)
Specificity: Antibody BU63 recognizes the CD86 molecule of 80 kd (3).
Functional Application: Antibody BU63 blocks MLR and blocks binding of soluble CD152-muIg fusion protein to CD86.
References:
1. C. Caux, et al, (1994) J Exp Med 180: 1841-1847.
2. C.B. Thompson, (1995) Cell 81: 979-982.
3. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 703-705.
4. D. Mauri, et al, (1995) J Immunol 155: 118-127.