anti-CD86 Purified (with Antibiotics)

Human CD86 (B7-2) is a costimulating ligand for CD28 and CTLA-4.  CD86 is expressed on activated B cells and blood monocytes (3).

Isotype: Murine IgG1

Immunogen: ARH-77 (B-lymphoblastoid cell line)

Specificity: Antibody BU63 recognizes the CD86 molecule of 80 kd (3).

Functional Application: Antibody BU63 blocks MLR and blocks binding of soluble CD152-muIg fusion protein to CD86.

References:

1.  C. Caux, et al, (1994) J Exp Med  180: 1841-1847.

2.  C.B. Thompson, (1995) Cell  81: 979-982.

3.  Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 703-705.

4.  D. Mauri, et al, (1995) J Immunol  155: 118-127.