Human p53 is a tumor suppressor protein which is mutated in many cancers (2). p53 expression has been linked to apoptosis caused by DNA-damaging agents (5) and may have a role in cell-mediated cytotoxicity (4).
Isotype: Murine IgG1 kappa
Immunogen: Murine p53 fragment expressed in E. coli
Specificity: Antibody PAb240 recognizes a denaturization resistant p53 epitope between amino acids 156-214. It is cross reactive with human, mouse, hamster, rat, bovine and chicken(6) tissues(1).
2. C.C. Harris and M. Hollstein (1993) New Engl J Med 329: 1318-1327.
3. H. Selter & M. Montenarch (1994) Int J Biochem 26: 145-154.
4. T. Mahdi, et al, (1995) Biol Cell 84: 175-185.
5. M.L. Smith and A.J. Fornace, Jr (1996) Am J Pathol 148: 1019-1022.