anti-p53 Purified (with Antibiotics)

Human p53 is a tumor suppressor protein which is mutated in many cancers (2).  p53 expression has been linked to apoptosis caused by DNA-damaging agents (5) and may have a role in cell-mediated cytotoxicity (4).      

Isotype: Murine IgG1 kappa

Immunogen: Murine p53 fragment expressed in E. coli

Specificity: Antibody PAb240 recognizes a denaturization resistant p53 epitope between amino acids 156-214.  It is cross reactive with human, mouse, hamster, rat, bovine and chicken(6) tissues(1).

References:

1.  J.V. Gannon, et al, (1990) EMBO J  9(5): 1595-1602.

2.  C.C. Harris and M. Hollstein (1993) New Engl J Med  329: 1318-1327.

3.  H. Selter & M. Montenarch (1994) Int J Biochem  26: 145-154.

4.  T. Mahdi, et al, (1995) Biol Cell  84: 175-185.

5.  M.L. Smith and A.J. Fornace, Jr (1996) Am J Pathol  148: 1019-1022.

6.  M Takagi, K Ohashi, et al. (2006) J Vet Med Sciences 68(6): 561-566.  PMID: 16820712.

7. M Li, L Puglielli, et al. (2015) Neurobiol of Aging 36(10): 2725-2736. https://doi.org/10.1016/j.neurobiolaging.2015.06.021

USD $175.00
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= $175.00
Catalog #:
227-020
Form:
Pur/WA
Size:
100 µg
Alternate Name:
Tumor supressor protein
Clone:
PAb240
Applications:
6), FC, IHC(1), WB(1

Application Key

FC
Flow Cytometry
WB
Western blot
EIA
Enzyme Immunoassay
IHC
Immunohistochemistry
ICC
Immunocytochemistry
FPS
Fixed paraffin section
PS
Paraffin section
IP
Immunoprecipitation
FX
Fixed cells or tissues

Applications indicated have been either tested in-house or reported. Products may be functional for applications not indicated.

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