anti-CD46 Purified (Preservative-free)

Human CD46 is a cell surface glycoprotein expressed on almost all human cells except erythrocytes.  CD46 is involved with regulation of complement activation and is also a measles virus receptor.

Isotype: Murine IgG2a

Immunogen: Human PBL and EBV transformed LCL

Specificity: Antibody 169-1-E4.3 recognizes the SCR1 epitope of CD46 (3).

Functional Application: Antibody 169-1-E4.3 does not block MCP function (3).  Ancell anti-CD46 has been used to detect acrosome-reacted human speratozoa (5), and for FACS phenotype of monocytes in measles patients(7).

References:

1.  R.L. Sparrow and I.F.C. McKenzie, (1983) Human Immunol 7: 1-15.

2.  D. Christiansen, et al, (1996) Eur J Immunol 26:  578-585.

3.  Leukocyte Typing VI (T. Kishimoto, et al, eds.) Garland Publishing, Inc., New York (1997) p. 506-509.

4. M Gokumakulapalle, Ya-Fang Mei, et al. (Oct 27, 2021) Front Microbiol 12: 698999. doi: 10.3389/fmicb.2021.698999  PMID: 34777270

5. M Frolikova, K Dvorakova-Hortova, et al. (2021 Oct 19)  Int J Mol Sci ;22(20):11263. doi: 10.3390/ijms222011263.

6. Madhuri Gokumakulapalle, Ya-Fang Mei, et al. (Oct 27, 2021) Front Microbiol 12:698999. doi: 10.3389/fmicb.2021.698999. eCollection 2021.

7. S P Yentur, G Saruhan-Direskeneli, et al. (Jan 7, 2021) PLOS ONE  https://doi.org/10.1371/journal.pone.0245077.

USD $175.00
In cart: 0
= $175.00
Catalog #:
197-820
Form:
Pur/PF
Size:
100 µg
Alternate Name:
MCP
Clone:
169-1-E4.3
Applications:
FC, WB

Application Key

FC
Flow Cytometry
WB
Western blot
EIA
Enzyme Immunoassay
IHC
Immunohistochemistry
ICC
Immunocytochemistry
FPS
Fixed paraffin section
PS
Paraffin section
IP
Immunoprecipitation
FX
Fixed cells or tissues

Applications indicated have been either tested in-house or reported. Products may be functional for applications not indicated.

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