Human CD38 is a type II transmembrane glycoprotein with bifunctional ectoenzyme activity catalyzing both synthesis and hydrolysis of cyclic ADP ribose (1). CD38 is involved in lymphocyte activation and adhesion to endothelium and has been identified as a counter-receptor of CD31 (2).
Isotype: Murine IgG1
Immunogen: Human T cell tumor cells: CEM
Specificity: Antibody AT1 recognizes the CD38 molecule of 45 kd. It is crossreactive with cynlomolgus macaque CD38, and recognizes a reduction-sensitive epitope (3).
1. Leukocyte Typing VI (T. Kishimoto, et al, eds.) Garland Publishing, Inc., New York (1997) p. 151-157.
2. S. Deaglio, et al, (1998) J Immunol 160:395-402.