anti-CD38 R-PE Conjugate

Human CD38 is a type II transmembrane glycoprotein with bifunctional ectoenzyme activity catalyzing both synthesis and hydrolysis of cyclic ADP ribose (1).  CD38 is involved in lymphocyte activation and adhesion to endothelium and has been identified as a counter-receptor of CD31 (2).

Isotype: Murine IgG1

Immunogen: Human T cell tumor cells: CEM

Specificity: Antibody AT1 recognizes the CD38 molecule of 45 kd.   It is crossreactive with cynlomolgus macaque CD38, and recognizes a reduction-sensitive epitope (3).

References:

1.  Leukocyte Typing VI (T. Kishimoto, et al, eds.) Garland Publishing, Inc., New York (1997) p. 151-157.

2.  S. Deaglio, et al, (1998) J Immunol 160:395-402.

3.  Ferrero E, Malavasi F (2004) BMC Immunology 5: 21.  PMID: 15383153

4.  James La Porta, Lori R Covey, et al. (2016) PLoS One 11(8):e0158708. PMID: 27513449

5.  Christina L Zuch de Zafra, Olivier Nolan-Stevaux, et al. (2019) Clin Canc Res 25(13): 3921-33. PMID: 30918018 DOI: 10.1158/1078-0432.CCR-18-2752.

USD $300.00
In cart: 0
= $300.00
Catalog #:
187-050
Form:
R-PE
Size:
120 tests
Alternate Name:
AT-1, ADP-ribosyl cyclase
Clone:
AT1
Applications:
FC, WB(3)

Application Key

FC
Flow Cytometry
WB
Western blot
EIA
Enzyme Immunoassay
IHC
Immunohistochemistry
ICC
Immunocytochemistry
FPS
Fixed paraffin section
PS
Paraffin section
IP
Immunoprecipitation
FX
Fixed cells or tissues

Applications indicated have been either tested in-house or reported. Products may be functional for applications not indicated.

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