Human CD10 is a well known marker for common acute lymphoblastic leukemia antigen (CALLA) (4). CD10 is expressed on normal early B cells in bone marrow and is also on fetal thymocytes. CD10 expression is lost as the T and B lineage cells mature and only appears again on activated germinal center B cells. CD10 is present on neutrophils. CD10 is a neutral endopeptidase and hydrolyzes peptide bonds on the amino side of hydrophobic amino acids.
Isotype: Murine IgG1kappa
Immunogen: Membrane preparation of human B-lineage leukemia cells
Specificity: Antibody SN5c recognizes an extracellular epitope of the the human 100 kd membrane-associated peptidase CD10 (1, 2, 3).
1. H. Matsuzaki, et al, (1987) Cancer Research 47: 2160-2166.
2. W.C. Biddle, et al, (1989) Leukemia Research 13: 699-707.
3. H. Hara, et al, (1988) Cancer Research 48: 4673-4680.
4. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 505-507.