anti-CD6 Biotinylated

Human CD6 is expressed on peripheral blood T cells, most thymocytes and a subset of B cells.  CD6 is similar to CD5 and contains three cysteine-rich domains with structural homology to the macrophage scavenger receptor.  CD6 is involved in T cell activation and its ligand was recently identified (2, 4).

Isotype: Murine IgG1kappa

Immunogen: Human rheumatoid synovial T cell line (ST-1)

Specificity: Antibody UCMCD6/3F7B5 recognizes an epitope within Domain 1 of the CD6 molecule of approximately 130 kd (5).

Functional Application: Antibody UMCD6 is a useful reagent to study T cell activation through CD6.

Reference:

1.  CM Bott, DA Fox, et al, (1993) Intl Immunol  5(7): 783-792.  PMID:7690243

2.  M.A. Bowen, et al, (1995) J Exp Med  181: 2213-2220.

3.  Leukocyte Typing V (S.F. Schlossman, et al, eds.)  Oxford University Press, Oxford, (1995)  p. 419-422.

4.  G.S. Whitney, et al, (1995) J Biol Chem  270: 18187-18190.

5. L Garner, MH Brown, et al. (Oct 2018) Immunolgy 155(2): 273-282. doi: 10.1111/imm.12952   PMID: 29772075.

USD $235.00
In cart: 0
= $235.00
Catalog #:
151-030
Form:
Biotin
Size:
100 µg
Alternate Name:
3F7B5, UMCD6
Clone:
UMCD6 / 3F7B5
Applications:
FC, FX, WB

Application Key

FC
Flow Cytometry
WB
Western blot
EIA
Enzyme Immunoassay
IHC
Immunohistochemistry
ICC
Immunocytochemistry
FPS
Fixed paraffin section
PS
Paraffin section
IP
Immunoprecipitation
FX
Fixed cells or tissues

Applications indicated have been either tested in-house or reported. Products may be functional for applications not indicated.

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