Human CD6 is expressed on peripheral blood T cells, most thymocytes and a subset of B cells. CD6 is similar to CD5 and contains three cysteine-rich domains with structural homology to the macrophage scavenger receptor. CD6 is involved in T cell activation and its ligand was recently identified (2, 4).
Isotype: Murine IgG1kappa
Immunogen: Human rheumatoid synovial T cell line (ST-1)
Specificity: Antibody UCMCD6 recognizes epitope 3 of the CD6 molecules of approximately 130 kd (1, 3).
Functional Application: Antibody UMCD6 is a useful reagent to study T cell activation through CD6.
2. M.A. Bowen, et al, (1995) J Exp Med 181: 2213-2220.
3. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 419-422.
4. G.S. Whitney, et al, (1995) J Biol Chem 270: 18187-18190.