Human CD2 is a T-lineage glycoprotein with roles in cell-cell adhesion and the transduction of activation signals. Multiple ligands for CD2 include CD58 (LFA-3), CD59, and CD48. CD2 may play a role in regulating T cell anergy (3).
Isotype: Murine IgG2a kappa
Immunogen: Human rheumatoid synovial T cell line (ST-1)
Specificity: Antibody UMCD2 recognizes the T111 epitope of the 50 kd human CD2 molecule (1, 2).
Functional Application: Antibody UMCD2/1E7E8 is useful for studying CD2 ligand-binding mechanisms involved with T cell development and activation. Biotinylated mAb has been used to stimulate T cells (4).
1) K.F. Kozarsky, et al, (1993) Cell Immunol 150: 235-246.
2) Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 342-352.
3) G.M. Bell & J.B. Imboden, (1995) J Immunol 155: 2805-2807.
4. S S Skanland, K Tasken, et al. (2014) Biochem J 460: 399-410. doi: 10.1042/BJ20140040