anti-CD2 R-PE Conjugate

Human CD2 is a T-lineage glycoprotein with roles in cell-cell adhesion and the transduction of activation signals.  Multiple ligands for CD2 include CD58 (LFA-3), CD59, and CD48.  CD2 may play a role in regulating T cell anergy (3).

Isotype: Murine IgG2a kappa

Immunogen: Human rheumatoid synovial T cell line (ST-1)

Specificity: Antibody UMCD2 recognizes the T111 epitope of the 50 kd human CD2 molecule (1, 2).

Functional Application: Antibody UMCD2/1E7E8 is useful for studying CD2 ligand-binding mechanisms involved  with T cell  development and activation. Biotinylated mAb has been used to stimulate T cells (4).

References:

1) K.F. Kozarsky, et al, (1993) Cell Immunol  150: 235-246.

2) Leukocyte Typing V (S.F. Schlossman, et al, eds.)  Oxford University Press, Oxford, (1995)  p. 342-352.

3) G.M. Bell & J.B. Imboden, (1995) J Immunol  155: 2805-2807.

4. S S Skanland, K Tasken, et al. (2014) Biochem J 460: 399-410. doi: 10.1042/BJ20140040

USD $275.00
In cart: 0
= $275.00
Catalog #:
143-050
Form:
R-PE
Size:
120 tests
Clone:
1E7E8
Applications:
FC

Application Key

FC
Flow Cytometry
WB
Western blot
EIA
Enzyme Immunoassay
IHC
Immunohistochemistry
ICC
Immunocytochemistry
FPS
Fixed paraffin section
PS
Paraffin section
IP
Immunoprecipitation
FX
Fixed cells or tissues

Applications indicated have been either tested in-house or reported. Products may be functional for applications not indicated.

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