anti-human IgA Purified (with Antibiotics)
Human immunoglobulins are glycoproteins composed of two disulfide-bonded heavy (H) chain subunits, each of which is linked by interchain disulfide bonds to a light (L) chain forming a tetramolecular complex. There are five classes of immunoglobulins, designated IgG, IgA, IgM, IgD and IgE, which are defined by differences in the constant region of H chains. L chains are divided into kappa or lambda classifications based on structural antigenic differences. All classes of immunoglobulins have been found on the cell surface of B lymphocytes where they function as antigen receptors to elicit antigen-dependent proliferation and secretion of antigen specific soluble circulating antibodies.
Isotype: Murine IgG1 kappa
Immunogen: Human salivary proteins
Specificity: Antibody Hisa43 recognizes the CH3 domain(2) of cell surface, serum and secretory(3) IgA
References:
1. Basic and Clinical Immunology, Seventh edition (D. P. Sites & A. I. Terr, eds.) Appleton & Lange., Norwalk, CT (1991).
2. J. Biewenga, et al, (1986) Mol Immunol 23: 761-767.
3. Biewenga J, S van der Baan, et al. (1991) Ann Clin Biochem 28: 260-266.PMID: 1872572 doi: 10.1177/000456329102800311