anti-human IgA Biotinylated

Human immunoglobulins are glycoproteins composed of two disulfide-bonded heavy (H) chain subunits, each of which is linked by interchain disulfide bonds to a light (L) chain forming a tetramolecular complex.  There are five classes of immunoglobulins, designated IgG, IgA, IgM, IgD and IgE, which are defined by differences in the constant region of H chains.  L chains are divided into kappa or lambda classifications based on structural antigenic differences.  All classes of immunoglobulins have been found on the cell surface of B lymphocytes where they function as antigen receptors to elicit antigen-dependent proliferation and secretion of antigen specific soluble circulating antibodies.

Isotype:  Murine IgG1 kappa

Immunogen:   Human salivary proteins

Specificity:   Antibody Hisa43 recognizes the CH3 domain(2) of cell surface, serum and secretory(3) IgA

References:

1.  Basic and Clinical Immunology, Seventh edition (D. P. Sites & A. I. Terr, eds.) Appleton & Lange., Norwalk, CT (1991).

2.  J. Biewenga, et al, (1986) Mol Immunol 23: 761-767.

3.  Biewenga J, S van der Baan, et al. (1991) Ann Clin Biochem 28: 260-266.PMID: 1872572  doi: 10.1177/000456329102800311 

4. Oortwijn B D, C vanKooten, et al. (2006) J Am Soc Nephrol 17: 3529 –3539, 2006. doi: 10.1681/ASN.2006040388

USD $210.00
In cart: 0
= $210.00
Catalog #:
137-030
Form:
Biotin
Size:
100 µg
Alternate Name:
IgA, anti-IgA, Immunoglobulin
Clone:
Hisa43
Categories:

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