anti-human IgA FITC Conjugate

Human immunoglobulins are glycoproteins composed of two disulfide-bonded heavy (H) chain subunits, each of which is linked by interchain disulfide bonds to a light (L) chain forming a tetramolecular complex.  There are five classes of immunoglobulins, designated IgG, IgA, IgM, IgD and IgE, which are defined by differences in the constant region of H chains.  L chains are divided into kappa or lambda classifications based on structural antigenic differences.  All classes of immunoglobulins have been found on the cell surface of B lymphocytes where they function as antigen receptors to elicit antigen-dependent proliferation and secretion of antigen specific soluble circulating antibodies.

Isotype:  Murine IgG1 kappa

Immunogen:   Human salivary proteins

Specificity:   Antibody Hisa43 recognizes the CH3 domain(2) of cell surface, serum and secretory(3) IgA

References:

1.  Basic and Clinical Immunology, Seventh edition (D. P. Sites & A. I. Terr, eds.) Appleton & Lange., Norwalk, CT (1991).

2.  J. Biewenga, et al, (1986) Mol Immunol 23: 761-767.

3.  Biewenga J, S van der Baan, et al. (1991) Ann Clin Biochem 28: 260-266.PMID: 1872572  doi: 10.1177/000456329102800311 

4. Oortwijn B D, C vanKooten, et al. (2006) J Am Soc Nephrol 17: 3529 –3539, 2006. doi: 10.1681/ASN.2006040388

USD $210.00
In cart: 0
= $210.00
Catalog #:
137-040
Form:
FITC
Size:
120 tests
Alternate Name:
IgA, anti-IgA, Immunoglobulin
Clone:
Hisa43
Applications:
EIA, FC

Application Key

FC
Flow Cytometry
WB
Western blot
EIA
Enzyme Immunoassay
IHC
Immunohistochemistry
ICC
Immunocytochemistry
FPS
Fixed paraffin section
PS
Paraffin section
IP
Immunoprecipitation
FX
Fixed cells or tissues

Applications indicated have been either tested in-house or reported. Products may be functional for applications not indicated.

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