anti-TCR Vβ3 FITC Conjugate
Human T cell receptor (TCR) is a T cell surface expressed heterodimer of alpha/beta or gamma/delta chains. TCR’s recognize antigen peptides bound to MHC molecules forming the basis of antigen specific response by T cells (3, 4).
Isotype: Murine IgG2a lambda
Immunogen: Human HA1.7 TCR beta chain expressed on transgenic mouse cells
Specificity: Antibody JOVI-3 is specific for the human V beta 3 TCR gene product and reacts with 1-10 of T cells in normal human blood (1, 5).
Functional Application: Antibody JOVI-3 is mitogenic for T cells expressing TCR V beta 3.
References:
1. J.L. Viney, et al, (1992) Hybridoma 11: 701-713.
2. A. Weiss, (1993) Cell 73: 209-212.
3. M.M. Daris, (1995) Nature 375: 104.
4. S. Valitutti, et al, (1995) Nature 375: 148-151.
5. Y Watanabe, K Sugamura, et al (2009) Int Immunol 21(7): 843-858. PMID: 19515798