Agonistic humanized anti-CD134(OX40) antibodies improve T effector cell function by depleting T regulatory cells in vitro.  This approach has great potential for augmenting cancer therapy! “Antibodies Targeting Human OX40 Expand Effector T Cells and Block Inducible and Natural Regulatory T Cell Function” K.S. Voo, Y.J. Liu, et al. (2013) J Immunol 191: 3641-3650. PMID: 24014877 […]

New Ancell Products for human Dendritic cell research! Recombinant human CD279(PD-1) (CHO cell host) Recombinant human CD273(B7-DC) (CHO cell host) anti-human CD279(PD-1) antibody (clone ANC4H6) anti-human CD273(B7-DC) antibody (clone ANC8D12)   Other related products anti-human CD274(B7-H1) antibody Recombinant human CD274(B7-H1) (CHO cell host) anti-CD11b antibody (clone ICRF44) anti-CD14 antibody (clone UCHM1)

The BTLA(CD272)-HVEM(CD270) pathway is an important regulatory mechanism for gamma/delta T cell proliferation. A subset of gamma/delta T cells can be induced to have potent anti-Lymphoma activity.  The amount of BTLA present on cell surface of these cells inversely correlates with their degree of differentiation. Blockade of this pathway can increases T cell signaling ability,

Stem Cell Factor (SCF) can activate Lung Mast cells through CD117 (c-kit) to become more responsive to IgE challenge in vitro.  Up regulation of CD63 can be used to track this activation “Heterogeneity in the responses of human lung mast cells to stem cell factor” A. Lewis, J. Wan, B. Baothman, P. N. Monk, S.

Lower Frequencies of Down-regulatory Fc receptor CD32B on Memory B cells in Rheumatoid Arthritis patients “CD40 Mediates Downregulation of CD32B on Specific Memory B Cell Populations in Rheumatoid Arthritis”  Xiaoyu Zhang, Scott E. Strome, et al. (2013 June 15,) J Immunol 190(12): 6015-22.   In RA patient samples, CD154 T cell expression levels correlated with

Featured product: Ancell anti-CD105/FITC clone SN6 In these studies, Mesenchymal Stem/Progenitor cells show potential for repairing damaged joint tissue, and restoring liver function.  After enriched by sorting, and expansion in culture, the phenotype of resulting stem cell populations are:  CD105+, CD29+, CD166+, CD44+, CD45-, CD31-. 1) “Adipose tissue-derived mesenchymal stem cells as a source of

Featured product: Ancell Biotinylated mAb cocktail effective for Negative selection of Low Density Granulocyte(LDG) population from Systemic Lupus Erythematosis (SLE) patient blood. “A Distinct Subset of Proinflammatory Neutrophils Isolated from Patients with Systemic Lupus Erythematosus Induces Vascular Damage and Synthesizes Type I IFNs “ M.F. Denny, M.J. Kaplan, et al.  (2010) J Immunol  184(6): 3284-3297

Featured Products: F(ab’)2 Fragments of anti-CD64(FcgRI), anti-CD32(FcgRII), and anti-CD16(FcgRIII) for Human Fc Receptor and Immune Complex  Research Low Endotoxin and Essentially Free of Intact Antibody, these dimericantibody fragments block Immunoglobulin binding to their repective receptors anti-human CD64 (FcgRI)F(ab’)2 clone 10.1 anti-human CD32 (FcgRII) F(ab’)2 clone 7.3 anti-human CD16 (FcgRIII) F(ab’)2 clone 3G8 Literature Citations Inhibition

New human biologically active CD273 ( B7-DC, PD-L2) recombinant protein and other related products now available!

SW480 is a primary Colon Epithelial Adenocarcinoma tumor line and SW620 is a metastasized variant of this derived from lymph node.  Differential analysis of surface markers may give insight into tumor metastatic potential and/or mechanisms.   “Multiplex Flow Cytometry Barcoding and Antibody Arrays Identify Surface Antigen Profiles of Primary and Metastatic Colon Cancer Cell Lines”