oxLDL-IC pathology was mediated by CD36 and CD64 receptors on retinal pericytes. “Immune complex formation in human diabetic retina enhances toxicity of oxidized LDL towards retinal capillary pericytes.” D Fu, T J Lyons, et al. (May, 2014) J Lipid Res 55: 860-869. PMID: 24616481 Ancell reagents were used in this study to selectively block IC […]
A matched pair of EIA antibodies to detect CD272(BTLA)
CD272(BTLA) EIA Tools Read More »
Autumn Immunolgy Conference in Chicago is November 21st through 24th. Visit our booth!
Ancell at AIC 2014 Read More »
Level of CD4+CD39+/CD161+ T cell sub population in muscosal membranes and peripheral blood correlate to severity of Crohns Disease. “CD39 and CD161 Modulate Th17 Responses in Crohn’s Disease” A Bai, S C Robson, et al. (2014) J Immunol 193(7): 3366-3377. PMID:25172498 Relevant Ancell antibodies and conjugates anti-human CD4 anti-human CD39 anti-human CD161
CD39 and CD161 are useful markers for observing Th17 inflammatory T cell response. Read More »
Human CD326 (EpCAM, EGP2, HEA) is a 40kD glycoprotein expressed on epithelial cells and many carcinomas. It is an adhesion molecule whose function is implicated in carcinogenesis and erythropoesis. CD326 has great potential as a therapeutic and diagnostic marker for cancer (2, 3). 1) Rao CG, et al. (2005) Int. J. Oncol 27: 49 2)
anti-CD326 antibodies now available Read More »
Using transgenic mouse models and BM transplantation, it was observed that numbers of expanded thymic Treg are proportionate to number of thymic B cells present during autoimmune development. “A Role for Intrathymic B Cells in the Generation of Natural Regulatory T Cells.” Stacey N Walters, Shane Grey, et al. (2014) J Immunol 193(1): 170-176. PMID:24872190
B cells play a role in thymic Treg expansion Read More »
CD273 binds to a distinct site on RGMb (Repulsive Guidance Molecule Family member B) from Bone Morphogenic proteins (BMP). In mice, blockade of this interaction impaired development of respiratory tolerance. “RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance” Y Xiao, G J Freeman, et al. (2014) JEM
RGMb (Dragon) identified as a ligand for CD273(PD-L2, B7-DC) Read More »
anti-GARP/FITC catalog #277-040 anti-GARP/PE catalog #277-050 anti-GARP/Biotin catalog #277-030 anti-GARP mAb catalog #277-020 Other Ancell human Treg Products CD4 CD39 CD357(AITR/GITR) CD45RA CD45RO CD127 CD25
Anti-human GARP antibody products now available Read More »
This German research group has developed a method to directly culture Pre and Pro B cells from CD34+ sorted Bone Marrow using cytokines and immobilized recombinant CD54. “A Feeder-Free Differentiation System Identifes Autonomously Proliferating B Cell precursors in Human Bone Marrow” H Kraus, M Rizzi, et al. (2014) J Immunol 192(3): 1044-1054. PMID: 24379121
Identifying B cell Precursors in Human Bone Marrow Read More »
“GARP regulates the bioavailability and activation of TGFbeta” R Wang, T A Springer, et al. (2012) Mol Biol Cell 23(6): 1129-1139. Look for new Ancell anti-GARP products March 2014! Ancell human Treg Products CD4 CD39 CD357(AITR/GITR) CD45RA CD45RO CD127 CD25
