room34

Lower Frequencies of Down-regulatory Fc receptor CD32B on Memory B cells in Rheumatoid Arthritis patients

Lower Frequencies of Down-regulatory Fc receptor CD32B on Memory B cells in Rheumatoid Arthritis patients “CD40 Mediates Downregulation of CD32B on Specific Memory B Cell Populations in Rheumatoid Arthritis”  Xiaoyu Zhang, Scott E. Strome, et al. (2013 June 15,) J Immunol 190(12): 6015-22.   In RA patient samples, CD154 T cell expression levels correlated with

Lower Frequencies of Down-regulatory Fc receptor CD32B on Memory B cells in Rheumatoid Arthritis patients Read More »

anti-CD105 fluorescent conjugates for phenotypic analysis of Mesenchymal Stem Cells

Featured product: Ancell anti-CD105/FITC clone SN6 In these studies, Mesenchymal Stem/Progenitor cells show potential for repairing damaged joint tissue, and restoring liver function.  After enriched by sorting, and expansion in culture, the phenotype of resulting stem cell populations are:  CD105+, CD29+, CD166+, CD44+, CD45-, CD31-. 1) “Adipose tissue-derived mesenchymal stem cells as a source of

anti-CD105 fluorescent conjugates for phenotypic analysis of Mesenchymal Stem Cells Read More »

Biotinylated mAb cocktail effective for isolating Low Density Granulocytes from SLE patient blood

Featured product: Ancell Biotinylated mAb cocktail effective for Negative selection of Low Density Granulocyte(LDG) population from Systemic Lupus Erythematosis (SLE) patient blood. “A Distinct Subset of Proinflammatory Neutrophils Isolated from Patients with Systemic Lupus Erythematosus Induces Vascular Damage and Synthesizes Type I IFNs “ M.F. Denny, M.J. Kaplan, et al.  (2010) J Immunol  184(6): 3284-3297

Biotinylated mAb cocktail effective for isolating Low Density Granulocytes from SLE patient blood Read More »

CD64 FcγRI, CD32FcγRII, CD16FcγRIII F(ab’)2

Featured Products: F(ab’)2 Fragments of anti-CD64(FcgRI), anti-CD32(FcgRII), and anti-CD16(FcgRIII) for Human Fc Receptor and Immune Complex  Research Low Endotoxin and Essentially Free of Intact Antibody, these dimericantibody fragments block Immunoglobulin binding to their repective receptors anti-human CD64 (FcgRI)F(ab’)2 clone 10.1 anti-human CD32 (FcgRII) F(ab’)2 clone 7.3 anti-human CD16 (FcgRIII) F(ab’)2 clone 3G8 Literature Citations Inhibition

CD64 FcγRI, CD32FcγRII, CD16FcγRIII F(ab’)2 Read More »

Cell Surface Metastatic Markers for Colon Cancer SW480/SW620 Model

SW480 is a primary Colon Epithelial Adenocarcinoma tumor line and SW620 is a metastasized variant of this derived from lymph node.  Differential analysis of surface markers may give insight into tumor metastatic potential and/or mechanisms.   “Multiplex Flow Cytometry Barcoding and Antibody Arrays Identify Surface Antigen Profiles of Primary and Metastatic Colon Cancer Cell Lines”

Cell Surface Metastatic Markers for Colon Cancer SW480/SW620 Model Read More »

Clinical Response to Prostate Cancer Immunotherapy using GM-CSF and anti-CD152 Correlates with Diversity of Upmodulated Antibody Binding to Microarray Antigens

“Diversity of Antigen-Specific Responses Induced In Vivo with CTLA-4 Blockade in Prostate Cancer Patients”   Kwek S S, L Fong, et al. (Oct 2012)  J Immunol 189(7): 3759-3766.  “…advanced prostate cancer patients who clinically respond to treatment also develop enhanced Ab responses to a higher number of Ags than nonresponders…” Relevant Ancell Products Anti-CD152(CTLA-4) blocking mAb

Clinical Response to Prostate Cancer Immunotherapy using GM-CSF and anti-CD152 Correlates with Diversity of Upmodulated Antibody Binding to Microarray Antigens Read More »