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Anti-CD47 H5F9-G4 antibody blocks CD47 – SIRPa interaction and has been shown to restore anti-cancer immunity in mouse models.  In recent human studies, initial drug dose showed promising effect and was well tolerated in combination with Rituximab(anti-CD20) with side effects of anemia, headache and fatigue.   Relevant Ancell Products New anti-human CD47 mAb

The authors prove the concept that an anti-TCR Cb1 CAR cell based on the epitope of Jovi-1 anti-TCR Cb1 mAb can kill malignant T cell leukemic cells without destroying TCR Cb2 cells.  ”Targeting the T cell receptor β-chain constant region for immunotherapy of T cell malignancies.” Paul M Maciocia, Martin A Pule, et al. (2017)

The authors surmise that the presence or absence of CD62L expression on these cells could be used as a diagnostic indicator of autoimmune diseases, such as Crohn. CD62L Is a Functional and Phenotypic Marker for Circulating Innate Lymphoid Cell Precursors  Yotam E. Bar-Ephraim, Reina E. Mebius et al.  J Immunol January 1, 2019, 202 (1)

Visit Ancell at the Autumn Immunology Conference in Chicago, booth T13  Fri Nov 16 through Mon Nov 19th !  We are proud to once again fund an Undergrad Outreach Sponsorship, as well as a Wallace Diversity Sponsorship.

CD47 is emerging as a promising intervention point in Cancer therapy. Head and Neck Squamous Cell Carcinoma:  Anti-CD47 treatment enhances anti-tumor T-cell immunity and improves immunosuppressive environment in head and neck squamous cell carcinoma.  Wu L, Sun ZJ, et al. (2018) Oncoimmunology 7(4): e1397248. Doi: 10.1080/2162402X.2017.1397248. Glioma:  Blocking the CD47-SIRPα axis by delivery of anti-CD47

Anti-GITR is proving to be another useful intervention checkpoint in cancer therapy.   Abstract 3813: Development of JNJ-64164711, a low fucose anti-GITR antibody for enhanced depletion of tumor regulatory T cells (Tregs) Cam V. Holland, John Kehoe, Judith Hailey, Rupesh Nanjunda, Eilyn Lacy, Robin Ernst, Di Zhang, Sam Wu, Alexey Teplyakov, Weimin Li, Michelle Kinder,

Interfering with the CD279(PD-1) – CD274(PD-L1) axis has shown great promise in restoring anti-cancer T cell function.  This Pittsburgh research group has used a similar approach in a mouse HSV-1 model to improve T cell mediated viral clearance from the immunologically sequestered cornea.   “PD-L1/B7-H1 Inhibits Viral Clearance by Macrophages in HSV-1–Infected Corneas” Sohyun Jeon,

Visit Ancell at Booth #231 at the American Association of Immunology annual meeting in Austin Texas May  4 – 8!

ANC28.1 mAb used as a Control in a Modified Chandler-loop model developed to screen and assess drug toxicity This system could potentially prevent disastrous clinical human trials like the TGN1412 (anti-CD28) one.   “Extracorporeal human whole blood in motion as a tool to predict first-infusion reactions and mechanism-of-action of immunotherapeutics”  E A K Fletcher, S

In CD28 knockout mice, TFR cells have diminished suppressive ability, and B cells cause systemic inflammation. “B Cells Drive Autoimmunity in Mice with CD28-Deficient Regulatory T Cells” Ruan Zhang, Laurence A. Turka, et al J Immunol December 15, 2017, 199 (12) 3972-3980; DOI: https://doi.org/10.4049/jimmunol.1700409