INFORMATION: The p75 low affinity human Nerve Growth Factor receptor CD271(NGRF, TNFRSF16) is expressed on a variety of tissue types including a subset of splenic and nodal lymphocytes. Presence of this receptor supports uptake of intracellular calcium, but not mobilization (3). CD271 is a stem cell marker for hematopoietic(5,6,7), stromal (8) as well as cancer cells (9,10). CD271 has been reported to inhibit differentiation of mesenchymal cells into various lineages(11).
Molecular Structure: A soluble fusion protein consisting of the extracellular (195aa) domain of human NGFR fused to murine IgG2a Fc (233aa). N-teminal sequence: (29)KEACP
Transfectant Cell Line: CHO :
Immunochemistry Applications: NGFR-muIg binds to coated NGFbeta in ELISA.
1) Brodie C, E W Gelfand (1992) Journal of Immunology. 148(11): 3492-3497.
2) Fantini F, O. Johansson (1992) Journal of Investigative Dermatology. 99(6): 734-742.
3) Jiang H, G Gurogg, et al.(1999) J Biol Chem 274(37): 26209-16.