CD271(NGFR)-muIg Purified (with Antibiotics)

INFORMATION: The p75 low affinity human Nerve Growth Factor receptor CD271(NGRF, TNFRSF16) is expressed on a variety of tissue types including a subset of splenic and nodal lymphocytes. Presence of this receptor supports uptake of intracellular calcium, but not mobilization (3). CD271 is a stem cell marker for hematopoietic(5,6,7), stromal (8) as well as cancer cells (9,10).  CD271 has been reported to inhibit differentiation of mesenchymal cells into various lineages(11).  

Molecular Structure:  A soluble fusion protein consisting of the extracellular (195aa) domain of human NGFR fused to murine IgG2a Fc (233aa).  N-teminal sequence: (29)KEACP

Transfectant Cell Line:  CHO :

Immunochemistry Applications: NGFR-muIg binds to coated NGFbeta in ELISA. 

References:

1) Brodie C, E W Gelfand (1992) Journal of Immunology. 148(11): 3492-3497.

2) Fantini F, O. Johansson  (1992) Journal of Investigative Dermatology. 99(6): 734-742. 

3) Jiang H, G Gurogg, et al.(1999) J Biol Chem 274(37): 26209-16.  

4) Khwaja F, D Djakiew, et al (2004) Cancer Res 64(17): 6207-13. 

5) Flores-Torales E,  Cuneo-Pareto S, et al. (2010) Folia Histochem Cytobiol. 48(4):682-6.

6) Kuçi S, Bader P, et al. (2010)  Haematologica. 95(4):651-9.

7) Hermida-Gómez T, Blanco FJ, et al. (2011) Tissue Eng Part A. 17(7-8):1169-79. 8) Jones E, McGonagle D, et al. (2010)  Arthritis Rheum. 62(7):1944-54.

9) Boiko AD, Weissman IL. Et al. (2010) Nature 466(7302):133-7. 

10) Civenni G, Sommer L, et al. (2011) Cancer Res. 71(8):3098-109.

11) Mikami Y, Honda MJ, et al. (2011) Stem Cells Dev. 20(5):901-13.

USD $325.00
In cart: 0
= $325.00
Catalog #:
527-020
Form:
Pur/WA
Size:
25 µg
Applications:
EIA

Application Key

FC
Flow Cytometry
WB
Western blot
EIA
Enzyme Immunoassay
IHC
Immunohistochemistry
ICC
Immunocytochemistry
FPS
Fixed paraffin section
PS
Paraffin section
IP
Immunoprecipitation
FX
Fixed cells or tissues

Applications indicated have been either tested in-house or reported. Products may be functional for applications not indicated.

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