CD271(NGFR)-muIg (Pur/WA)

INFORMATION: The p75 low affinity human Nerve Growth Factor receptor CD271(NGRF, TNFRSF16) is expressed on a variety of tissue types including a subset of splenic and nodal lymphocytes. Presence of this receptor supports uptake of intracellular calcium, but not mobilization (3). CD271 is a stem cell marker for hematopoietic(5,6,7), stromal (8) as well as cancer cells (9,10). CD271 has been reported to inhibit differentiation of mesenchymal cells into various lineages(11).

Molecular Structure: A soluble fusion protein consisting of the extracellular (195aa) domain of human NGFR fused to murine IgG2a Fc (233aa). N-teminal sequence: (29)KEACP

Transfectant Cell Line: CHO :

Immunochemistry Applications: NGFR-muIg binds to coated NGFbeta in ELISA.

References:

1) Brodie C, E W Gelfand (1992) Journal of Immunology. 148(11): 3492-3497.

2) Fantini F, O. Johansson (1992) Journal of Investigative Dermatology. 99(6): 734-742.

3) Jiang H, G Gurogg, et al.(1999) J Biol Chem 274(37): 26209-16.

4) Khwaja F, D Djakiew, et al (2004) Cancer Res 64(17): 6207-13.

5) Flores-Torales E, Cuneo-Pareto S, et al. (2010) Folia Histochem Cytobiol. 48(4):682-6.

6) Kuçi S, Bader P, et al. (2010) Haematologica. 95(4):651-9.

7) Hermida-Gómez T, Blanco FJ, et al. (2011) Tissue Eng Part A. 17(7-8):1169-79. 8) Jones E, McGonagle D, et al. (2010) Arthritis Rheum. 62(7):1944-54.

9) Boiko AD, Weissman IL. Et al. (2010) Nature 466(7302):133-7.

10) Civenni G, Sommer L, et al. (2011) Cancer Res. 71(8):3098-109.