anti-TNF α R-PE Conjugate

Human tumor necrosis factor alpha (TNF alpha) is a proinflammatory cytokine expressed mainly by activated monocytes and macrophages.  TNF alpha exerts a key role with regard to pathogenesis of many infectious and inflammatory diseases.

Isotype: Murine IgG1

Immunogen: Recombinant human TNF alpha

Functional Application: Antibody J1D9 neutralizes TNF alpha biological activities (2). It prevents TNF alpha induced apoptosis in Jurkat cells (5).

References:

1.  P. Vassalli, (1992) Annu Rev Immunol  10: 411-452.

2.  P.J. McLaughlin, et al, (1992) Anticancer Res  12: 1243-1246.

3.  M. Pasparakis, et al, (1996) Cytokine and Growth Factor Reviews  7: 223-229.

4.  A. Eigler, et al, (1997) Immunology Today  18: 487-492.

5. Kalli K R, Kaufmann S H, et al. (2003) Molecular Pharmacology 64(6): 1434-1443.

USD $300.00
In cart: 0
= $300.00
Catalog #:
398-050
Form:
R-PE
Size:
120 tests
Alternate Name:
Tumor Necrosis Factorα', TNFα
Clone:
J1D9
Applications:
FC, FX, WB

Application Key

FC
Flow Cytometry
WB
Western blot
EIA
Enzyme Immunoassay
IHC
Immunohistochemistry
ICC
Immunocytochemistry
FPS
Fixed paraffin section
PS
Paraffin section
IP
Immunoprecipitation
FX
Fixed cells or tissues

Applications indicated have been either tested in-house or reported. Products may be functional for applications not indicated.

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