Human CD137 Ligand is a type II transmembrane protein constitutively expressed by monocytes, B cells neuroblastoma cells (1), and some activated T cells. The interaction of CD137 (4-1BB) and CD137L can supply a costimulatory signal to T cells through CD137. This costimulus seems to be more effective for CD8+ effector T cells than for CD4+ helper T cells (3). The interaction can also effect a reverse signal, inducing monocyte activation (2), or T cell inactivation and programmed death (4) through CD137L.
Isotype: Murine IgG2a kappa
Immunogen: Recombinant human CD137L
Specificity: Antibody ANC5D6 binds to an extracellular epiopte of human CD137L present on Raji and U-937 cells, and also binds to recombinant CD137L-muCD8 in EIA and Western Blot (6).
Functional Application: Antibody ANC5D6 does not block the interaction between CD137L and CD137.
1) M.R. Alderson, et al, (1994) Eur J Immunol 24 : 2219-2227.
2) J. Langstein, et al, (1998) J Immunol 160: 2488-2494 .
3) V.Y. Taraban, et al, (2002) Eur J. Immunol. 32: 3617-3627.
4) H. Schwartz, et al, (1996) Blood 87: 2839.
5) G. Zhu, et al, (2001) J Immunol 167: 2671-6.