anti-CD137L Purified (with Antibiotics)

Human CD137 Ligand is a type II transmembrane protein constitutively expressed by monocytes, B cells neuroblastoma cells (1), and some activated T cells. The interaction of CD137 (4-1BB) and CD137L can supply a costimulatory signal to T cells through CD137. This costimulus seems to be more effective for CD8+ effector T cells than  for CD4+ helper T cells (3).  The interaction can also effect a reverse signal, inducing monocyte activation (2), or T cell inactivation and programmed death (4) through CD137L.

Isotype: Murine IgG2a kappa

Immunogen: Recombinant human CD137L

Specificity: Antibody ANC5D6 binds to an extracellular epiopte of human CD137L present on Raji and U-937 cells, and also binds to recombinant CD137L-muCD8 in EIA and Western Blot (6).

Functional Application: Antibody ANC5D6 does not block the interaction between CD137L and CD137.

References:

1) M.R. Alderson, et al, (1994) Eur J Immunol 24 : 2219-2227. 

2) J. Langstein, et al, (1998) J Immunol 160: 2488-2494 .

3) V.Y.  Taraban, et al, (2002) Eur J. Immunol. 32: 3617-3627.

4) H. Schwartz, et al, (1996) Blood 87: 2839. 

5) G. Zhu, et al, (2001) J Immunol 167: 2671-6.

6) Q Mei, Han W, et al. (2015) J Pathol 236(2): 165-74. PMID: 25727216

USD $210.00
In cart: 0
= $210.00
Catalog #:
365-020
Form:
Pur/WA
Size:
100 µg
Alternate Name:
4-1BBL
Clone:
ANC5D6
Applications:
EIA, FC, WB(6)

Application Key

FC
Flow Cytometry
WB
Western blot
EIA
Enzyme Immunoassay
IHC
Immunohistochemistry
ICC
Immunocytochemistry
FPS
Fixed paraffin section
PS
Paraffin section
IP
Immunoprecipitation
FX
Fixed cells or tissues

Applications indicated have been either tested in-house or reported. Products may be functional for applications not indicated.

1
Categories:

Downloads