anti-TIGIT Purified (Preservative-free)

Isotype:  Mouse IgG1k

Immunogen:  Recombinant human TIGIT

INFORMATION: Human TIGIT (T cell immunoreceptor with Ig and ITIM domains) is a co inhibitory receptor expressed by activated T cells, memory T cells, Treg cells and NK cells.  It binds to CD155(PVR) and less avidly to CD112(PVRL2). Blockade of the TIGIT/CD155 axis shows promise in restoring T cell function in pancreatic cancer(2).

Specificity: Antibody ANCTG6 binds to receptors on a sub set of  human peripheral blood lymphoid cells, as well as to recombinant TIGIT in EIA.

References:

1)  Dougall WC, AC Anderson, et al. (2017) Immunol Rev 276(1): 112-120. doi: 10.1111/imr.12518 PMID: 28258695

2) Freed-Pastor WA, Tyler Jacks, et al. (July 2021) Cancer Cell S1535-6108(21)00384-6. doi: 10.1016/j.ccell.2021.07.007

USD $235.00
In cart: 0
= $235.00
Catalog #:
340-820
Form:
Pur/PF
Size:
100 µg
Alternate Name:
T cell immunoreceptor with Ig and ITIM domains
Clone:
ANCTG6/10A6
Applications:
EIA, FC

Application Key

FC
Flow Cytometry
WB
Western blot
EIA
Enzyme Immunoassay
IHC
Immunohistochemistry
ICC
Immunocytochemistry
FPS
Fixed paraffin section
PS
Paraffin section
IP
Immunoprecipitation
FX
Fixed cells or tissues

Applications indicated have been either tested in-house or reported. Products may be functional for applications not indicated.

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