Isotype: Mouse IgG1k
Immunogen: Recombinant human TIGIT
INFORMATION: Human TIGIT (T cell immunoreceptor with Ig and ITIM domains) is a co inhibitory receptor expressed by activated T cells, memory T cells, Treg cells and NK cells. It binds to CD155(PVR) and less avidly to CD112(PVRL2). Blockade of the TIGIT/CD155 axis shows promise in restoring T cell function in pancreatic cancer(2).
Specificity: Antibody ANCTG6 binds to receptors on a sub set of human peripheral blood lymphoid cells, as well as to recombinant TIGIT in EIA.
1) Dougall WC, AC Anderson, et al. (2017) Immunol Rev 276(1): 112-120. doi: 10.1111/imr.12518 PMID: 28258695
2) Freed-Pastor WA, Tyler Jacks, et al. (July 2021) Cancer Cell S1535-6108(21)00384-6. doi: 10.1016/j.ccell.2021.07.007