anti-CD105 Biotinylated

Human CD105 (endoglin) is a homodimeric membrane glycoprotein (1) virtually restricted to endothelial cells, and present on some leukemia cells and minor subsets of bone marrow cells.  CD105 binds to TGF-b1 and b3 with high affinity (4).

Isotype: Murine IgG1 kappa

Immunogen: Membrane preparation of human B-lineage leukemia cells

Specificity: Antibody SN6 recognizes an extracellular epitope of the human CD105 homodimer with a molecular weight of about 160 kd. It has been reported to cross react with non human Primate as well as Equine and Porcine(11) CD105.

Functional Application: Antibody SN6 will augment binding of TGF-b1 to CD105 expressing leukemia cells.  Antibody SN6 has been used to identify mesenchymal progenitor cell sub populations (8,9,10,13)

References:

1.  Y. Haruta & B.K. Seon, (1986) Proc Natl Acad Sci USA  83: 7898-7902.

2.  H. Hara, et al, (1988) Cancer Res  48: 4673-4680.

3.  W.C. Biddle, et al, (1989) Leukemia Res  13: 699-707.

4.  S. Cheifetz, et al, (1992) J Biol Chem  267: 19027-19030.

5.  B.K. Seon, et al, (1995) Proc Am Assoc Can Res  36: 23.

6.  Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 1756-1761, 1762-1764.

7.  B.K. Seon, et al, (1996) Tissue Antigens  48: 417.

8.  S Alsalameh, M Lotz, et al. (2004) Arthritis & Rhematism 50(5): 1522-1532.

9. A Banas, T Ochiya, et al. (2007) Hepatology 46: 219-228.

10. R Williams, HE McCathy, et al. (2010) PLoS ONE 5(10): e13246  doi:10.1371.

11. G Vilahur, L Badimon, et al. Oct 13, 2014 Toxicol Pathol pii: 0192623314551971.

12.  M Vigano,  de Girolamo, et al. (Feb 2017) J Exp Orthopaedics 4: 8.

13. M.T. Weickert, KS Gotze, et al. (2021 Mar 15) Sci Rep 11(1): 5944 doi: 10.1038/s41598-021-85122-8.

14. L N Muench, J Mehl, et al. (July 2021) J Arthroscopy 37(7): 2043-52. https://doi.org/10.1016/j.arthro.2021.01.064.

USD $210.00
In cart: 0
= $210.00
Catalog #:
326-030
Form:
Biotin
Size:
100 µg
Alternate Name:
Endoglin
Clone:
SN6/N1-3A1
Applications:
FC(12), IHC

Application Key

FC
Flow Cytometry
WB
Western blot
EIA
Enzyme Immunoassay
IHC
Immunohistochemistry
ICC
Immunocytochemistry
FPS
Fixed paraffin section
PS
Paraffin section
IP
Immunoprecipitation
FX
Fixed cells or tissues

Applications indicated have been either tested in-house or reported. Products may be functional for applications not indicated.

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