anti-CD98 Biotinylated

Human CD98 (4F2) is a heterodimeric glycoproein expressed on monocytes and activated cells.  All cultured human cell lines tested express CD98.  CD98 heavy chain mediates adhesion induced activation through integrin signalling (4) .

Isotype: Murine IgG1

Immunogen: Molt 13 T cell line

Specificity: Antibody UM7F8 recognizes the heavy chain of a 125 kd heterodimeric membrane glycoprotein CD98 (1-3 ).

Functional Application: Antibody UM7F8 is comitogenic with soluble anti-CD2 and immobilized anti-CD3 mAbs (1).

References:

1.  AW Friedman, DA Fox, et al. (1994) Cell Immunol  154: 253-263.

2.  Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 280-283.

3.  Leukocyte Typing VI (T. Kishimoto, et al, eds.) Garland Publishing, Inc., New York (1997) p. 531-534.

4.  Feral CC, Ginsberg MH, et al. (2005) PNAS USA 102(2): 355-360.