anti-CD62L Purified (Preservative-free)

Human CD62L is as adhesion molecule found on most leukocytes and plays a primary role in mediating initial leukocyte interaction with activated vascular endothelium (1).  Human CD62L has signal transduction functions where engagement leads to increased calcium levels and upregulated expression of certain integrins (2).

Isotype: Murine IgG2a Kappa

Immunogen: Mouse pre-B cells expressing human L-selectin

Specificity: Antibody LAM1-116 recognizes the lectin binding domain of human, mouse, rat and guinea pig CD62L (2, 4).  It has also been reported to recognize equine, canine and bovine CD62L.

Functional Application: Antibody LAM1-116 blocks CD62L function and induces expression of beta-1 and beta-2 integrins (1).

References:

1.  T.A. Springer, (1995) Annu Rev Physiol  57: 827-872.

2.  D.A. Steeber, et al, (1997) J Immunol 159:  952-963.

3.  Leukocyte Typing VI (T. Kishimoto, et al, eds.) Garland Publishing, Inc., New York  (1997) p. 420-424.

4.  A.D. Fryer, B.S. Bochner, et al  (1997)  J Clin Invest 99(8): 2036-2044.

USD $175.00
In cart: 0
= $175.00
Catalog #:
261-820
Form:
Pur/PF
Size:
100 µg
Alternate Name:
L-selectin, SELL
Clone:
LAM1-116
Applications:
FC

Application Key

FC
Flow Cytometry
WB
Western blot
EIA
Enzyme Immunoassay
IHC
Immunohistochemistry
ICC
Immunocytochemistry
FPS
Fixed paraffin section
PS
Paraffin section
IP
Immunoprecipitation
FX
Fixed cells or tissues

Applications indicated have been either tested in-house or reported. Products may be functional for applications not indicated.

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